Ursodeoxycholic Acid Tablets BP 150mg

Product Description

Ursodeoxycholic Acid 150 mg Tablets BP is a medication used primarily to treat gallstones and certain liver conditions. It is a bile acid that naturally occurs in the body and has been used therapeutically to improve liver function and treat diseases involving bile production and flow.

Common Uses:

1. Gallstones (Cholesterol Stones): Ursodeoxycholic acid is used to dissolve cholesterol-based gallstones in patients who are not candidates for surgery or for whom surgery is not an option. It helps reduce the cholesterol content of the bile and can gradually dissolve the stones over time.
2. Primary Biliary Cirrhosis (PBC): Ursodeoxycholic acid is used in the treatment of primary biliary cirrhosis, a chronic liver disease where the bile ducts become damaged, causing liver dysfunction. It helps improve liver function and reduce the progression of the disease.
3. Liver Disorders: It can also be used to treat certain liver conditions like hepatitis or liver damage caused by other diseases.

Mechanism of Action:

Ursodeoxycholic acid is a bile acid that works by:

• Reducing cholesterol levels in bile: By reducing the cholesterol content, it helps to dissolve cholesterol-based gallstones and prevent new ones from forming.
• Improving liver function: It can protect liver cells from damage by stabilizing cell membranes and reducing the toxic effects of other bile acids that may accumulate due to liver disease.
• Improving bile flow: It increases the flow of bile, which helps in the digestion and absorption of fats, especially in conditions like PBC.

Dosage and Administration:

• For Gallstones: The typical dose is 300“600 mg per day in divided doses, depending on the size and number of gallstones. The dose is often started at a lower level and gradually increased.
• For Primary Biliary Cirrhosis (PBC): The recommended dose for adults is typically 13“15 mg/kg body weight per day, divided into two or three doses.
• Timing: Ursodeoxycholic acid tablets are usually taken with food to improve absorption.
• Duration: The treatment duration can vary, but it may take several months for gallstones to dissolve. Liver conditions may require long-term therapy.

Possible Side Effects:

Common side effects of Ursodeoxycholic Acid include:

• Diarrhea or loose stools (especially in the initial stages of treatment)
• Stomach pain or indigestion
• Nausea
• Fatigue or weakness

Less common, but serious side effects may include:

• Severe abdominal pain, which could indicate gallbladder problems.
• Jaundice (yellowing of the skin or eyes), indicating potential liver issues.
• Allergic reactions (rash, itching, swelling, trouble breathing).

Precautions:

1. Gallbladder Disease: Ursodeoxycholic acid should be used with caution in patients with severe gallbladder disease, especially if the gallbladder is not functioning properly (e.g., gallbladder stones that are calcified or causing significant inflammation).
2. Liver Disease: Although Ursodeoxycholic acid can help in certain liver conditions, it should be used cautiously in people with severe liver dysfunction. Monitoring liver function during treatment is important.
3. Pregnancy and Breastfeeding: Ursodeoxycholic acid should be used in pregnancy only if absolutely necessary, and under a doctor's guidance. It is unclear if Ursodeoxycholic acid passes into breast milk, so consult your healthcare provider if you are pregnant or breastfeeding.
4. Kidney Function: Caution is advised if you have kidney problems, as renal function should be monitored periodically.
5. Drug Interactions: Inform your doctor of all medications you are taking, especially if you're using medications for liver diseases, cholesterol-lowering drugs, or antacids. Certain drugs, like cholestyramine (used for lowering cholesterol), may interfere with Ursodeoxycholic acid's action.

Important Notes:

• Regular Monitoring: During treatment, your doctor may monitor liver enzymes, gallbladder function, and overall liver function through blood tests.
• Dietary Considerations: While on Ursodeoxycholic acid, following a low-fat diet may help with bile acid metabolism and prevent the formation of new gallstones.
• Consistency: Take the medication exactly as prescribed, and do not miss doses. If you forget a dose, take it as soon as you remember unless it™s almost time for your next dose.

Lifestyle Considerations:

• Diet: A balanced, low-fat diet can help support your treatment and may help prevent further complications related to gallstones and liver diseases.
• Exercise: Regular physical activity can help with overall liver health and weight management, which may reduce the risk of gallstone formation.