Neukine 300mcg Pfs

Product Description

Neukine 300 mcg Vial contains Lenograstim, which is a granulocyte colony-stimulating factor (G-CSF). G-CSF is a type of growth factor that stimulates the production of white blood cells, specifically neutrophils, which are essential for fighting infections.

Key Uses:

1. Chemotherapy-Induced Neutropenia: Neukine is primarily used to prevent or treat neutropenia (low white blood cell count) that is caused by chemotherapy. Chemotherapy can damage the bone marrow, leading to a decrease in neutrophils and an increased risk of infection. Neukine helps stimulate the bone marrow to produce more neutrophils.

2. Bone Marrow Disorders: It is also used in patients with bone marrow disorders, such as myelodysplastic syndromes or acute myeloid leukemia (AML), to support the recovery of the bone marrow.

3. Post-Surgical or Post-Transplant: In certain situations, Neukine may be used after surgery or bone marrow transplants to promote faster recovery of white blood cell counts.

Mechanism of Action:

Lenograstim is a recombinant form of the human granulocyte colony-stimulating factor (G-CSF). It works by binding to specific receptors on the surface of the bone marrow cells, stimulating them to produce and release more neutrophils into the bloodstream. These neutrophils help the body fight bacterial infections and support immune function.

Common Side Effects:

• Bone pain: One of the most common side effects, as G-CSF can cause bone marrow stimulation, leading to discomfort or pain in the bones.
• Fever or chills.
• Headache.
• Fatigue.
• Nausea.

Serious Side Effects:

• Splenic rupture: In rare cases, there can be a risk of splenic rupture (enlargement of the spleen or splenic injury).
• Leukocytosis: Overproduction of white blood cells, which can increase the risk of some types of blood disorders.
• Allergic reactions: Skin rashes, swelling, or more severe reactions like difficulty breathing.
• Respiratory issues: Rarely, patients may experience difficulty breathing or other respiratory problems.

Dosage:

The typical dosage of Neukine 300 mcg Vial depends on the patient's condition and response to treatment. The medication is usually administered as an injection under the skin (subcutaneous) or into the vein (intravenous). The exact dosage and frequency will be determined by a healthcare provider, but it is often given daily or several times a week.

Administration:

• Subcutaneous Injection: The 300 mcg vial is reconstituted with the provided diluent and is administered as a subcutaneous injection.
• Intravenous Infusion: In certain cases, it may be administered intravenously.

Precautions:

• Blood Counts: Close monitoring of blood counts is important during treatment to ensure that the white blood cell count doesn't rise too high.
• Bone Marrow Function: Patients with pre-existing bone marrow disorders should be monitored carefully as Neukine stimulates bone marrow.
• Allergic Reactions: If signs of an allergic reaction, such as rash, swelling, or difficulty breathing, occur, the treatment should be discontinued, and immediate medical attention is necessary.
• Pregnancy and Breastfeeding: The safety of Neukine during pregnancy and breastfeeding has not been established, so it should only be used if absolutely necessary and under strict medical supervision.

Summary:

Neukine 300 mcg Vial is a recombinant G-CSF used to stimulate the production of neutrophils in patients with neutropenia, particularly due to chemotherapy. It helps reduce the risk of infections by increasing white blood cell production. Common side effects include bone pain, fever, and fatigue, while more serious side effects can include splenic rupture and allergic reactions. Regular monitoring of blood counts and bone marrow function is essential.