Mofilet 500 Mg Tablets

Product Description

Mofilet 500 mg Tablets contain Mycophenolate Mofetil, which is an immunosuppressive drug. It is primarily used to prevent organ rejection in patients who have received kidney, heart, or liver transplants. It works by suppressing the immune system to prevent the body from attacking the transplanted organ.

Key Uses:

1. Organ Transplantation: Mofilet 500 mg Tablets are commonly used in combination with other immunosuppressive medications (such as cyclosporine or tacrolimus) to prevent rejection of kidney, heart, or liver transplants.

2. Autoimmune Diseases: It is sometimes used in the treatment of certain autoimmune diseases like lupus nephritis (a type of kidney inflammation due to lupus) and rheumatoid arthritis when other treatments are not sufficient or well-tolerated.

Mechanism of Action:

Mycophenolate Mofetil is converted in the body into its active form, mycophenolic acid. This active form works by inhibiting the enzyme inosine monophosphate dehydrogenase (IMPDH), which is crucial for the production of purines. Purines are necessary for the proliferation of B-cells and T-cells”important components of the immune system. By blocking this enzyme, Mycophenolate Mofetil reduces the production of these immune cells, thereby suppressing immune responses, including the body's rejection of transplanted organs.

Common Side Effects:

• Gastrointestinal issues: Nausea, vomiting, diarrhea, or abdominal pain.
• Headache or dizziness.
• Increased risk of infection due to suppressed immune function.
• Fatigue or weakness.
• Skin rashes or itching.

Serious Side Effects:

• Infections: Due to the immunosuppressive effect, Mofilet 500 mg can increase the risk of serious infections, including bacterial, viral, and fungal infections.
• Blood disorders: It can cause low white blood cells (leukopenia), low red blood cells (anemia), or low platelets (thrombocytopenia), leading to an increased risk of bleeding or infections.
• Liver toxicity: Mofilet 500 mg may cause liver damage, and liver function tests should be monitored regularly.
• Pregnancy risks: Mycophenolate Mofetil is known to cause birth defects and is contraindicated during pregnancy. It is essential to avoid pregnancy during treatment, and women should use reliable birth control methods.

Dosage:

The typical dose of Mofilet 500 mg Tablets varies based on the patient™s condition and the transplant type. The general starting dose for transplant patients is typically 1 gram (2 tablets of 500 mg) twice daily, but the exact dose will depend on individual health needs and the prescribing physician™s recommendations. It is usually taken orally with or without food.

Precautions:

• Pregnancy: Mofilet 500 mg is contraindicated during pregnancy due to the risk of birth defects. Women of childbearing age should use two forms of contraception during treatment and for 6 weeks after discontinuation.
• Infections: Due to its immunosuppressive nature, Mofilet 500 mg can increase the risk of infections, so it™s important to monitor for signs of infection, such as fever or sore throat.
• Blood counts: Regular blood tests are necessary to monitor for any adverse effects on blood cell counts (such as leukopenia, anemia, or thrombocytopenia).
• Liver and kidney function: Regular monitoring of liver and kidney function is important as Mofilet 500 mg may affect both organs.

Summary:

Mofilet 500 mg Tablets contain Mycophenolate Mofetil, an immunosuppressive medication used primarily for the prevention of organ rejection in transplant patients and for the treatment of certain autoimmune diseases. It works by suppressing the immune system to prevent it from attacking the transplanted organ. Common side effects include gastrointestinal upset, headache, and fatigue, while more serious side effects can include infections, blood disorders, and liver toxicity. Mofilet 500 mg is contraindicated during pregnancy due to the risk of birth defects and should be used with caution under medical supervision. Regular monitoring of blood counts, liver, and kidney function is required during treatment.