Irinotel 100 Mg Injection

Product Description

Irinotel 100 mg Injection contains irinotecan, which is a chemotherapy drug used primarily to treat cancers. It is classified as a topoisomerase I inhibitor, and it works by interfering with the DNA of cancer cells, thereby preventing them from dividing and growing.

Indications

Irinotecan is typically used for:

• Colorectal cancer (especially in combination with other chemotherapy agents)
• Other cancers: It may also be used for some types of ovarian, lung, or gastric cancer.

Mechanism of Action

Irinotecan works by inhibiting the enzyme topoisomerase I, which is crucial for DNA replication and repair. By inhibiting this enzyme, irinotecan prevents the cancer cells from properly replicating their DNA, leading to cell death.

Dosage and Administration

• Typical dose: The dose of irinotecan depends on factors like the type of cancer, body surface area, and the combination of drugs used in the treatment regimen.
• Administration: It is administered intravenously (IV) by a healthcare professional, usually over a period of 90 minutes or longer. It may be given once every two or three weeks, depending on the cancer type and treatment protocol.

Side Effects

Irinotecan can cause several side effects, including:

• Common side effects:
  • Nausea and vomiting
  • Diarrhea (can be severe and requires prompt treatment)
  • Fatigue
  • Hair loss
  • Low blood counts (including low white blood cell count, increasing the risk of infection)
• Serious side effects:
  • Severe diarrhea: This is one of the more significant side effects. Patients are often given medication to manage it.
  • Infections: Due to its effect on blood cells, irinotecan can make you more susceptible to infections.
  • Liver toxicity: The drug can affect liver function, so liver enzymes may need to be monitored during treatment.

Precautions and Warnings

• Diarrhea: Irinotecan can cause both early and late-onset diarrhea. Early diarrhea may occur shortly after the infusion and can often be treated with atropine. Late-onset diarrhea can occur several days later and may be more severe.

• Bone marrow suppression: Regular blood tests are necessary to monitor for low white blood cells, red blood cells, and platelets.

• Liver function: Since irinotecan is metabolized by the liver, patients with liver problems need special monitoring.

• Infection: Because of the risk of low white blood cell count, patients need to be closely monitored for infections, and antibiotics may be prescribed if necessary.

Important Considerations

• Hydration and anti-nausea medications may be given to help manage side effects like dehydration from diarrhea and nausea.

• Drug interactions: Irinotecan may interact with other medications, so it™s crucial to inform your doctor about any other drugs you are taking (including over-the-counter and herbal supplements).

Irinotecan is often used as part of a chemotherapy regimen, meaning it is combined with other medications to increase its effectiveness against cancer. If you're receiving irinotecan, it™s important to have a healthcare team to monitor for side effects and adjust treatment as needed.