Evaparin 300mg Injection

Product Description

Evaparin 300 mg Injection contains Enoxaparin Sodium, a type of low molecular weight heparin (LMWH). It is used primarily as an anticoagulant (blood thinner) to prevent and treat blood clots and conditions associated with abnormal blood clotting.

Indications

Enoxaparin (Evaparin) is used for:

1. Prevention of Deep Vein Thrombosis (DVT): After surgeries like hip replacement, knee replacement, or abdominal surgeries, Enoxaparin helps prevent the formation of clots in the deep veins of the legs or pelvis.
2. Treatment of DVT: It is used to treat existing DVT, preventing the clot from growing or moving to the lungs.
3. Prevention of Pulmonary Embolism (PE): It prevents clots from traveling to the lungs, which can be life-threatening.
4. Acute Coronary Syndrome (ACS): Enoxaparin is used in patients with unstable angina or non-ST elevation myocardial infarction (NSTEMI), conditions where blood clots can obstruct blood flow to the heart.
5. Prevention of clot formation during hemodialysis: Enoxaparin is used to prevent clotting in patients undergoing dialysis.
6. Other Uses: In some cases, it may be used in combination with other medications to prevent clots in high-risk patients.

Mechanism of Action

Enoxaparin works by inhibiting Factor Xa and thrombin, which are both key players in the blood clotting cascade. By enhancing the effects of antithrombin III, it reduces the ability of blood to form clots. This helps to prevent the formation of new clots and prevents existing clots from growing.

Dosage and Administration

• Typical Dosage:

  • Prevention of DVT: The typical dose is 30 mg every 12 hours or 40 mg once daily, depending on the type of surgery and the patient's condition.
  • Treatment of DVT/PE: For treating DVT or PE, the typical starting dose is 1 mg/kg every 12 hours via subcutaneous injection.
  • Acute Coronary Syndrome: The usual dose for patients with NSTEMI is 30 mg IV bolus followed by 1 mg/kg subcutaneously every 12 hours.

• Administration: Evaparin is typically administered via subcutaneous injection (under the skin), usually in the abdomen or thigh. In some cases, intravenous (IV) administration is used in hospital settings.

Side Effects

Common side effects of Enoxaparin (Evaparin) include:

• Injection site reactions: Pain, redness, or swelling where the injection is given.
• Bruising: Increased bruising may occur due to its blood-thinning effect.
• Low platelet count (thrombocytopenia): This can lead to increased risk of bleeding.

Serious side effects:

• Bleeding: As an anticoagulant, the most serious side effect is bleeding, which can include spontaneous bleeding, nosebleeds, or more severe bleeding events like internal bleeding.
• Heparin-induced thrombocytopenia (HIT): A rare but serious reaction where platelet levels drop significantly and increase the risk of blood clot formation despite anticoagulation.
• Severe allergic reactions: Although rare, some people may experience severe allergic reactions like anaphylaxis.
• Osteoporosis (long-term use): Rarely, long-term use of LMWH can lead to bone thinning.

Precautions and Warnings

• Risk of bleeding: Enoxaparin should be used with caution in patients who have active bleeding or a high risk of bleeding (e.g., recent surgery, gastrointestinal bleeding, or peptic ulcers).
• Kidney function: In patients with renal (kidney) impairment, dosing may need to be adjusted.
• Pregnancy: Enoxaparin is generally considered safe to use during pregnancy for conditions like DVT or PE, but should only be used when necessary, as it passes into breast milk in small amounts.
• Surgery or invasive procedures: If you are planning a surgery or undergoing an invasive procedure, you may need to stop using Enoxaparin temporarily to reduce bleeding risk.

Important Considerations

• Monitoring: Routine blood clotting tests (e.g., aPTT) are typically not required for Enoxaparin as with unfractionated heparin, but platelet counts and other markers should be monitored, especially for prolonged use.
• Other medications: Enoxaparin can interact with other blood-thinning medications (e.g., aspirin, warfarin), so it™s important to inform your doctor about all the medications you're taking.
• Home use: Some patients can be trained to give subcutaneous injections at home. It is important to follow injection techniques properly and rotate injection sites to avoid irritation.

Conclusion

Evaparin (Enoxaparin) is a highly effective medication for preventing and treating blood clots, especially in high-risk patients following surgery or in conditions like DVT, PE, or acute coronary syndrome. It is a type of low-molecular-weight heparin that works by inhibiting key clotting factors. While effective, it requires careful monitoring to prevent side effects like bleeding or thrombocytopenia.