Dasacine Dasatinib 50mg tablets

Product Description

Dasacine Dasatinib 50mg Tablets is a medication used primarily in the treatment of certain types of leukemia and other cancers. The active ingredient, Dasatinib, is a tyrosine kinase inhibitor that works by blocking signals that promote the growth of cancer cells.

Key Details about Dasacine Dasatinib 50mg Tablets:

Active Ingredient:

• Dasatinib (50 mg per tablet) is the active ingredient in Dasacine tablets. Dasatinib is a potent oral tyrosine kinase inhibitor that targets multiple kinases involved in the growth and proliferation of cancer cells.

Mechanism of Action:

Dasatinib inhibits the activity of several tyrosine kinases, enzymes that play a role in cancer cell growth and survival. It primarily targets the BCR-ABL fusion protein, which is present in Philadelphia chromosome-positive (Ph+) cancers. In addition to BCR-ABL, Dasatinib also inhibits other kinases involved in cancer cell proliferation, including SRC family kinases and KIT, both of which contribute to the development of leukemia and other cancers.

By blocking these signaling pathways, Dasatinib can halt the growth of cancer cells and reduce the spread of tumors.

Indications (Uses):

Dasacine Dasatinib 50mg tablets are primarily used for:

1. Chronic Myeloid Leukemia (CML): Particularly for patients with Philadelphia chromosome-positive (Ph+) CML in both chronic phase and accelerated phase.
2. Acute Lymphoblastic Leukemia (ALL): For Philadelphia chromosome-positive (Ph+) ALL in both newly diagnosed and relapsed cases.
3. Other cancers: It is also used in the treatment of other cancers like Dermatofibrosarcoma Protuberans (DFSP) and Gastrointestinal Stromal Tumors (GISTs) in certain situations.

Dosage:

• Typical Dosage: The usual dose of Dasatinib for Philadelphia chromosome-positive CML or Ph+ ALL is generally 50 mg once daily.

• The dose may be adjusted depending on the individual™s condition, response to treatment, and side effects.

• For chronic phase CML, the usual dose is 100 mg once daily, but 50 mg is often used for patients who cannot tolerate higher doses.

• Administration: The tablets should be taken orally, with a full glass of water. They can be taken with or without food. Swallow the tablet whole; do not crush or chew it.

Side Effects:

Common side effects of Dasatinib include:

• Fatigue,
• Headache,
• Nausea or vomiting,
• Diarrhea,
• Rash or skin reactions,
• Muscle pain or joint pain.

Serious side effects may include:

• Low blood cell counts: Dasatinib can cause a reduction in white blood cells, red blood cells, and platelets, which can lead to anemia, increased risk of infection, or easy bruising/bleeding.
• Fluid retention: This can cause swelling in the legs, ankles, or around the eyes.
• Heart problems: Dasatinib can lead to heart failure, QT prolongation (a heart rhythm issue), and pulmonary arterial hypertension (high blood pressure in the lungs).
• Liver toxicity: Elevated liver enzymes or jaundice (yellowing of the skin or eyes) may occur, which indicates potential liver damage.
• Respiratory issues: Rarely, it can cause pulmonary edema (fluid in the lungs), pleural effusion (fluid around the lungs), or other lung complications.

Serious Side Effects (Less Common but Severe):

• Severe heart problems: Chest pain, palpitations, or shortness of breath may signal heart failure.
• Severe bleeding: If you experience unusual bleeding or bruising, this may be due to low platelet counts.
• Liver problems: Yellowing of the skin/eyes, dark urine, or severe abdominal pain may indicate liver damage.
• Lung problems: Shortness of breath, dry cough, or swelling of the lungs may be signs of pulmonary issues.

Precautions:

• Blood cell counts: Regular monitoring of blood cell counts (white blood cells, red blood cells, and platelets) is necessary since Dasatinib can cause low blood cell counts.
• Liver function: Liver enzymes should be checked regularly. Dasatinib should be used cautiously in people with liver issues.
• Heart monitoring: Dasatinib can cause heart issues like QT prolongation or pulmonary hypertension, so regular cardiac monitoring may be recommended, especially if you have a history of heart disease.
• Pulmonary complications: Patients should be monitored for signs of lung problems, including difficulty breathing or swelling.
• Pregnancy and breastfeeding: Dasatinib is not recommended during pregnancy as it may harm the developing fetus. It should also be avoided during breastfeeding due to the risk of passing the drug through breast milk.
• Drug interactions: Dasatinib can interact with other medications, especially those that affect CYP3A4 enzymes (like ketoconazole, ritonavir, rifampin), which may alter the effectiveness of Dasatinib or increase the risk of side effects.

Drug Interactions:

• CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, ritonavir): These can increase Dasatinib blood levels, raising the risk of side effects.
• CYP3A4 Inducers (e.g., rifampin, carbamazepine): These can reduce Dasatinib levels, making it less effective.
• Anticoagulants (e.g., warfarin): Dasatinib can interact with blood thinners and may require dose adjustments.

Storage:

• Room Temperature: Store the tablets at 20C to 25C (68F to 77F).
• Keep away from moisture and heat.
• Out of reach of children to prevent accidental ingestion.

Conclusion:

Dasacine Dasatinib 50mg Tablets are effective in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), and other cancers like Gastrointestinal Stromal Tumors (GISTs). Dasatinib works by inhibiting specific kinases that are crucial for the survival and growth of cancer cells. However, its use requires monitoring for side effects such as low blood counts, heart issues, and liver toxicity. Regular follow-up with a healthcare provider is important to ensure optimal treatment and to manage any potential complications.